Chemotherapy and salivary pH in adults with cancer: an analytical cross-sectional study at a hospital in Cajamarca, Peru
DOI:
https://doi.org/10.64716/zp0zk802Palabras clave:
Neoplasms, Antineoplastic Agents, Saliva, Hydrogen-Ion Concentration, AdultResumen
Introduction: Chemotherapy may disrupt salivary gland function and alter oral acid–base balance, increasing susceptibility to dental caries, infections, and mucosal complications. Objetive: This study aimed to determine the association between chemotherapy duration and salivary pH in adults with cancer treated at a hospital in Cajamarca, Peru. Methods: An observational, analytical, cross-sectional study with prospective data collection was conducted in 68 adults selected through convenience sampling. Chemotherapy duration was obtained from oncology medical records, and the pH of unstimulated whole saliva was measured using a calibrated digital pH meter. Associations were evaluated using the chi-square test in IBM SPSS Statistics version 27, with statistical significance established at p < 0.05. Results: Acidic salivary pH was identified in 58.8% of participants, neutral pH in 35.3%, and alkaline pH in 5.9%. Chemotherapy duration was significantly associated with salivary pH (p = 0.002); acidic pH was observed in 74.3% of patients treated for 6 months or longer, compared with 15.4% of those treated for up to 1 month. In stratified analyses, the association remained significant among women (p = 0.001) and adults aged 36–50 years (p = 0.002), but not among men (p = 0.356) or participants aged 18–35 years (p = 0.907). Conclusion: Longer chemotherapy exposure was associated with greater salivary acidification, supporting the inclusion of salivary monitoring in multidisciplinary oral care for adults receiving prolonged cancer treatment.
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The de-identified dataset and the corresponding variable coding used in this study are available from the corresponding author upon reasonable and justified request. Access will be provided in accordance with participant confidentiality, ethical approval conditions, and applicable institutional regulations
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Derechos de autor 2026 Frida Hoyos-Sagastegui (Autor/a)
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Authors retain the copyright of their work and grant TUMI Oral Health the right of first publication. Articles are published under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
